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. 2023 Sep 10;12(9):1747. doi: 10.3390/antiox12091747

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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A scheme of SOD1 involvement in antigen-dependent T cell response. Recognition of antigen by TCR, inside MHC complex expressed on the surface of the Antigen Presenting Cell, induces rapid recruitment of SOD1 molecules near the TCR clusters; this phenomenon is accompanied by increased SOD1-mRNA, followed by SOD1 export by a microvesicle pathway. Extracellular SOD1 has been observed to mediate enhanced IL17 production by activated T lymphocytes. This effect depends on enzymatic activity of SOD1; the involvement of IL17 in induction/maintenance of chronic proinflammatory processes has been extensively studied by others. The image has been partially created by using BioRender.com.