Table 1.
Effects of plumbagin (PLUM) and praziquantel (PZQ) on worm burdens (total and female) and oogram of mice infected with S. mansoni.
| Experimental Groups |
Average Worm Burden | % Of Eggs per Developmental Stage | |||||
|---|---|---|---|---|---|---|---|
| Total | Reduction (%) | Female | Reduction (%) |
Immature * | Mature | Dead | |
| Control | 32.14 ± 2.73 | - | 14.29 ± 1.6 | - | 53.99 ± 5.81 | 41.39 ± 5.88 | 4.57 ± 0.61 |
| PZQ (50 mg/kg) | 0.8 ± 0.44 a | 97.51 | 0.4 ± 0.54 a | 97.2 | 0.0 ± 0.0 g | 2.37 ± 1.4 | 97.63 ± 1.4 h |
| PLUM | |||||||
| 8 mg/kg | 17.13 ± 1.72 a | 46.7 | 8.0 ± 1.63 a | 44.01 | 29.67 ± 3.2 g | 32.33 ± 5.31 | 38.33 ± 4.41 h |
| 16 mg/kg | 14.38 ± 1.84 a,b | 55.25 | 6.75 ± 0.89 a | 52.76 | 25.57 ± 3.64 g | 35.0 ± 55 | 39.43 ± 6.29 h |
| 32 mg/kg | 8.87 ± 1.12 a,c,d | 72.4 | 4.12 ± 0.99 a,e,f | 71.16 | 18.83 ± 4.53 g | 37.0 ± 6.54 | 44.17 ± 7.41 h |
a p < 0.001 compared to the respective control, total worms, or female worms; b p < 0.1; c p < 0.001 compared to the total worm load at the 8 mg/kg dose; d p < 0.001 when compared to the total burden of worms at the dose of 16 mg/kg; e p < 0.001 when compared to the burden of female worms at a dose of 8 mg/kg; f p< 0.1 when compared to the total load of worms at a dose of 16 mg/kg; g p< 0.001 compared to the percentage of immature eggs in the control group; h p< 0.001 compared to the percentage of dead eggs in the control group.