Table 2.

Template for intervention description and replication (TIDieR) checklist.

Brief Name	➢Whole-Body Photobiomodulation Therapy—18 sessions
Why	➢Eighteen sessions are the currently recommended and widely instituted and accepted practice with the NovoTHOR® device. ➢This device was developed in 2013, and since then, 251 NovoTHOR® systems have been developed of which 217 systems are still in regular use, treating at least four patients per device per day. This equates to approximately 1.6 million treatments since its inception. No significant adverse events have been reported to date.
What	➢All participants entering the trial will receive a course of whole-body PBMT. ➢The NovoTHOR® Whole-Body PBMT device consists of a hinged, clamshell design with light-emitting diodes (LEDs) arranged to emit near-infrared and visible red light → PBMT is delivered to the entire body at once. ➢A Participant Information Sheet (PIS) will be provided at least 48 h before participants are requested to consent to the study. They will be given the opportunity to undertake an experience session. ➢Participants will be expected to lie horizontally in the device with the lid as closed as they are comfortable with.
Who provided	➢All trial investigators, following a short training session in the use of NovoTHOR®.
How	➢The LED equipment delivers red and near infrared light therapy to the participant (as per the settings illustrated in Table 2).
Where	➢Clinical Research Facility, SWB NHS Trust. ➢Participants are registered at the Trust and are, therefore, geographically within the region. ➢The device requires a well-ventilated, spacious, temperature-controlled room, with appropriate mains electricity.
When and how much	➢Session 1 = 6 min. ➢Session 2 = 12 min. ➢Sessions 3–18 = 20 min. ➢Timescale: 3 treatments/week for 6 weeks. ➢The dosage of LED light (also known as ‘fluence’) will be equivalent to 25 J/cm2. The device will supply a dual wavelength of red and near-infrared light with a 50:50 ratio; 660 nm and 850 nm, respectively.
Tailoring	➢After liaison with experienced clinicians within the field with experience dealing with our population in the NovoTHOR®, we decided to slowly uptitrate the treatment times during the first three treatments for all participants.
Modifications	➢Described in ‘Results’ section.
How well	➢Described in ‘Results’ section.