The mean differences between macroscopic scores of each experimental group. The macroscopic scores were analyzed using a Kruskal–Wallis test followed by Dunn’s test for post-hoc testing for all groups. The experimental groups are as follows: PBS only, treated with sterile PBS; PBS + SP, treated with sterile PBS after bacterial inoculation; MRS + SP, treated with 20-fold concentrated sterile MRS broth after bacterial inoculation; DA + SP, treated with clindamycin (11 mg/kg) after bacterial inoculation; CFS + SP, treated with 20-fold concentrated L. animalis SWLA-1-derived CFS after bacterial inoculation. Significant differences between groups are denoted by asterisks (*: p < 0.05, ****: p < 0.0001). PBS, Phosphate buffered saline; SP, Staphylococcus pseudintermedius; MRS, Man Rogosa and Sharpe broth; DA, clindamycin; CFS, cell-free supernatant. The outliers were present by the bullets in the figure. The mean of observed data in each experimental group was present by the horizontal bold line in the figure.