Table 1.

Synthetic Data on Hydrogen Sulfide and Oxidative Stress.

Ref.	Title	Synthetic Data on Hydrogen Sulfide and Oxidative Stress	Outcomes
[8]	Effect of Hydrogen Sulfide on Essential Functions of Polymorphonuclear Leukocytes	Distinct from information available until 2022, this article emphasizes the dual nature of H2S in inflammation, acting both as a pro-inflammatory and anti-inflammatory molecule. It also elaborates on the complex interactions of H2S with various signaling pathways, its effects on different organ systems, and its potential therapeutic applications. The detailed exploration of H2S’s role in renal disease, including its interaction with uremic toxins and its impact on oxidative stress, offers a novel perspective that contributes to the understanding of H2S’s function in human health and disease.	The article elucidates the dual role of hydrogen sulfide (H2S) in inflammation, its complex interactions with signaling pathways, and its potential therapeutic applications, particularly in renal disease.
[10]	Advances of H2S in Regulating Neurodegenerative Diseases by Preserving Mitochondria Function	A comprehensive insight into the multifaceted role of H2S in neurodegenerative diseases, emphasizing its neuroprotective properties. It delves into the specific mechanisms through which H2S modulates mitochondrial activity, produces reactive sulfur species, and modifies proteins through sulfhydration. The article emphasizes the potential therapeutic applications of H2S in regulating neurodegenerative diseases through anti-oxidative, anti-inflammatory, anti-apoptotic, and S-sulfhydration.	The article reveals hydrogen sulfide’s dual role as a neuromodulator and neuroprotectant, offering new therapeutic avenues in neurodegenerative diseases.
[14]	SOD1 is an essential H2S detoxifying enzyme	Contrary to the prevailing knowledge until 2022, the paper uncovers the role of superoxide dismutase [Cu-Zn] (SOD1) as an efficient H2S oxidase, essential in limiting cytotoxicity from both endogenous and exogenous sulfide. It highlights SOD1’s ability to convert H2S to sulfate under limiting sulfide conditions rapidly and its role in forming per- and polysulfides, which induce cellular thiol oxidation.	The article reveals SOD1’s role as an H2S oxidase, essential in limiting H2S cytotoxicity, and regulating reactive sulfur species, enriching our understanding of H2S detoxification.
[43]	Generation and Physiology of Hydrogen Sulfide and Reactive Sulfur Species in Bacteria	The article presents a nuanced understanding of hydrogen sulfide’s (H2S) role in the oxidative stress response, highlighting its combinatorial redox action with hydrogen peroxide (H2O2) in mediating cytotoxicity and its contrasting protective effect against ROS-mediated killing. This complex interplay, including the formation of sulfheme iron complexes and the impact on catalases, adds to the existing knowledge by elucidating the multifaceted roles of H2S in oxidative stress and immunometabolism.	The article reveals hydrogen sulfide’s dual role in oxidative stress, mediating cytotoxicity and offering protection against ROS-mediated killing, enhancing understanding of immunometabolism.
[86]	Hydrogen Sulfide: A Gaseous Mediator and Its Key Role in Programmed Cell Death, Oxidative Stress, Inflammation, and Pulmonary Disease	The article advances the understanding of hydrogen sulfide (H2S) in oxidative stress, emphasizing its dual role as an antioxidant and a pro-oxidant. It highlights the complex mechanisms of H2S in quenching free radicals and its potential therapeutic targeting in pulmonary diseases, adding nuance to existing knowledge.	Insights into the tightly controlled metabolism of H2S in mammals, achieved through physiological enzymes catalyzed reactions.
[87]	Hydrogen sulfide: A new therapeutic target in vascular diseases	Emphasizes the intricate relationship between H2S and oxidative stress in regulating blood pressure. It details the mechanisms by which H2S acts as a vasorelaxant agent, its interaction with nitric oxide (NO), and the effects of various H2S donors in treating HBP. The potential of H2S as a therapeutic target for hypertension, including its role in inhibiting inflammation, suppressing vascular smooth muscle cell proliferation, and mitigating oxidative stress, thereby contributing to the understanding of H2S’s multifaceted role in cardiovascular health.	The article reveals hydrogen sulfide’s multifaceted role in regulating hypertension, emphasizing its potential as a therapeutic target in cardiovascular health.
[88]	Hydrogen Sulphide-Based Therapeutics for Neurological Conditions: Perspectives and Challenges	A comprehensive insight into the catabolism of H2S and its role in oxidative stress within the brain. Specifically, it highlights the interplay between enzymes, like sulfide quinone oxidoreductase (SQR) and its homolog SQRDL, along with neuroglobin, in the metabolism of H2S in the brain. Emphasizes the protective effect of H2S against oxidative stress by enhancing the synthesis of glutathione (GSH) and directly scavenging ROS. Explores the potential therapeutic applications of H2S donors in various neurological conditions, including Parkinson’s and Alzheimer’s diseases, offering a more refined understanding of H2S’s multifaceted role.	The article elucidates the complex role of hydrogen sulfide (H2S) in neuroprotection, highlighting its potential therapeutic applications in neurodegenerative disorders and emphasizing the need for further research to understand its multifaceted functions.
[89]	H2S regulation of ferroptosis attenuates sepsis-induced cardiomyopathy	The article presents new insights into the role of sodium hydrosulfide (NaHS) in alleviating sepsis-induced cardiomyopathy (SIC). Specifically, it demonstrates that NaHS mitigates oxidative stress and lipid peroxidation in cardiomyocytes, highlighting its potential as a therapeutic target for SIC. This adds to understanding NaHS’s anti-inflammatory, anti-oxidative stress, and anti-apoptotic properties and its regulation of pathways involved in sepsis multiorgan injury.	The study reveals that NaHS alleviates sepsis-induced cardiomyopathy by reducing oxidative stress and lipid peroxidation, suggesting therapeutic potential.
[90]	Sulfur content in foods and beverages and its role in human and animal metabolism: A scoping review of recent studies	The text highlights recent insights into sulfur dioxide’s physiological and toxicological roles (SO2) and its derivatives, emphasizing their complex effects on oxidative stress, gastrointestinal health, and food preservation. It contrasts previous understanding by detailing SO2’s potential preventive role in colitis, its impact on the gut microbiome, and its intricate interaction with various biological pathways.	The article reveals new insights into SO2’s roles in oxidative stress, colitis prevention, and gut microbiome interaction.
[91]	Dose-Dependent Effect of Hydrogen Sulfide in Cyclophosphamide-Induced Hepatotoxicity in Rats	This study introduces new insights into the role of hydrogen sulfide (H2S) in mitigating cyclophosphamide (CP)-induced hepatotoxicity. It emphasizes the protective effects of NaHS, an H2S donor, against liver damage caused by CP, a chemotherapeutic agent. The research highlights how H2S attenuates oxidative stress in the liver, including regulating critical enzymes and interactions with nitric oxide (NO). This adds to the existing knowledge by elucidating the potential therapeutic applications of H2S in preventing drug-induced liver injury.	The study reveals hydrogen sulfide’s potential in mitigating cyclophosphamide-induced hepatotoxicity, highlighting therapeutic applications in preventing drug-induced liver injury.