Table 2.

Synthetic Data on Hydrogen Sulfide and Cellular Homeostasis.

Ref.	Title	Synthetic Data on Hydrogen Sulfide and Cellular Homeostasis	Outcomes
[11]	Hydrogen Sulfide (H2S) Signaling as a Protective Mechanism against Endogenous and Exogenous Neurotoxicants	H2S mediates redox homeostasis, inflammatory response, mitochondrial functions, and synaptic transmission. New findings on H2S’s regulation of SIRT1 expression, its interaction with CREB, and its involvement in reducing homocysteine (Hcy)-induced endoplasmic reticulum stress (ERS), thus extending previous knowledge on its neuroprotective effects.	New insights detail hydrogen sulfide’s role in neuroprotection, redox homeostasis, SIRT1 regulation, and the reduction in Hcy-induced ERS.
[13]	From Gasotransmitter to Immunomodulator: The Emerging Role of Hydrogen Sulfide in Macrophage Biology	The paper emphasizes H2S as a potent inflammatory mediator, modulating macrophage activities, such as migration, phagocytosis, and cytokine production. Additionally, the article underscores H2S’s involvement in maintaining GSH levels, thus contributing to cellular redox homeostasis.	Recent findings emphasize H2S as an inflammatory mediator in macrophages, contributing to cellular homeostasis.
[63]	Recent Development of the Molecular and Cellular Mechanisms of Hydrogen Sulfide Gasotransmitter	The article highlights novel insights into H2S’s role in cellular homeostasis, emphasizing the interactions between H2S and other gasotransmitters, like NO and CO. It particularly illustrates how H2S can persulfidate specific enzymes, impacting various signaling pathways, and reveals new findings on H2S in the regulation of endocytosis, autophagy, and renal sodium homeostasis dysfunction. This information expands our understanding of H2S’s multifaceted roles in cellular processes.	H2S regulates endocytosis, autophagy, and renal sodium homeostasis dysfunction.
[83]	Protein persulfidation: Rewiring the hydrogen sulfide signaling in cell stress response	The article emphasizes the process of persulfidation as a biological switch in the cell stress response. The explanation of H2S’s biphasic model, where its levels operate within an optimal concentration range for health, represents an advancement in understanding its dynamic regulation of biological homeostasis, potentially opening novel therapeutic avenues.	Persulfidation’s significance in stress response and the revelation of H2S’s biphasic model
[94]	The Impact of Drugs on Hydrogen Sulfide Homeostasis in Mammals	This review highlights a novel aspect of H2S’s role in cellular homeostasis by emphasizing its interaction with commonly prescribed pharmacological drugs. Specifically, it catalogs the impact of these drugs on H2S production in mammalian cells and tissues, providing new insights into their influence on various physiological and pathological conditions.	The review reveals the impact of pharmacological drugs on hydrogen sulfide production in mammalian systems.
[96]	Mitochondria in endothelial cells angiogenesis and function: current understanding and future perspectives	The text highlights novel insights into H2S’s role in endothelial cell (EC) angiogenesis and mitochondrial function. Specifically, it elucidates the dual role of H2S in mitochondrial metabolism, showing its function enhancement at low concentrations and inhibition at high concentrations.	Explanation of H2S’s impact on specific enzymes and signaling pathways related to angiogenesis.
[97]	H2S- and Redox-State-Mediated PTP1B S-Sulfhydration in Insulin Signaling	This article introduces new insights into the role of H2S in cellular homeostasis, specifically in the context of insulin signaling. Furthermore, the report reveals the differential effects of insulin and metformin on H2S and GSH levels in different cell lines, thereby enriching our understanding of the role of H2S in insulin signaling and redox regulation.	It emphasizes the significance of PTP1B S-sulfhydration mediated by H2S and the redox state in insulin response and regulation.
[98]	Hydrogen sulfide plays an important role by regulating endoplasmic reticulum stress in myocardial diseases	This article introduces the emerging understanding of H2S’s role in regulating endoplasmic reticulum (ER) stress in myocardial diseases, a subject not widely explored until recently. The text emphasizes the novel findings on H2S’s involvement in physiological and pathological processes related to ER stress.	H2S’s involvement in physiological and pathological processes related to ER stress.
[99]	Epigenetic regulation of macrophage polarization in wound healing	The article explores the intricate role of H2S in the polarization and function of macrophages in cardiac pathophysiology, including atherosclerosis. Specifically, it highlights the inhibition of cystathionine γ-lyase (CSE) expression and H2S production in macrophages by homocysteine (Hcy) and the contribution of the dysregulated CSE-H2S signaling pathway to atherosclerosis pathogenesis.	Dysregulation of the CSE- H2S signaling pathway in macrophages contributes to atherosclerosis pathogenesis, with homocysteine (Hcy) affecting macrophage polarization.