Figure 10.

The participation of the PI3K/Akt pathway in the deregulation of AChE. Activation of the RTK receptors, nAChRs, and mAChRs could trigger the PI3K/Akt pathway, decreasing AChE content and AChE activity. The low AChE activity could increase ACh levels that stimulate nAChRs and mAChRs, increasing a sustained hyperactivation of the PI3k/Akt and MAP kinase pathways that promote cell proliferation, survival, and sustained AChE decrement. The AchE decrement could affect the apoptosome formation, increasing survival. Created with Biorender.com (accessed on 12 June 2023).