Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Sep 14;11(9):2535. doi: 10.3390/biomedicines11092535

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

pPDLSCs contain a subset of senescent cells. The stemness genes SOX2, OCT4, and NANOG were more expressed in pPDLSCs than in hPDLSC * p < 0.05 (A), as well as the senescence genes p16 and p21, * p < 0.01 (B). Among hPDLSCs the β-Gal staining was negative, while for pPDLSCs many cells were β-Gal+, confirming the senescent state (C,D). The intra-cytoplasmic and -nucleus staining showed a subset of PDLSCs, contemporary expressing stemness (OCT4) and senescent (p21) markers (E), where x indicates the mean value of the % of PDLSCs positive for both OCT4 and p21. The immunofluorescence staining showed more cells co-expressing OCT4 and p21 (white arrows) in pPDLSCs than in hPDLSCs (F,G).