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. 2023 Sep 14;11(9):2535. doi: 10.3390/biomedicines11092535

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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RG108 affects the senescent phenotype of pPDLSCs. RG108 did not show any significant variation of p16 and p21 expression in hPDLSCs for any of the conditions (A). In pPDLSCs, RG108 at 100 μM induced a significant reduction of both p16 and p21, p < 0.05 (B). The expression of the stemness genes, SOX2, OCT4, and NANOG was not significantly modulated in hPDLSCs (C), whereas an increase of SOX2 (p < 0.05) and of OCT4 (p < 0.01) was induced by treatment with RG108 at 100 μM (D). RG108 decreased the subset of pPDLSCs co-expressing OCT4 and p21 (p < 0.05), while no significant modulation was detected on hPDLSCs (E).