Figure 8.

Immune classes and subclasses of hepatocellular carcinoma. For each immune subclass, tumor immune microenvironment and molecular and genetic characterization are shown. HCCs can be divided into two major immune classes: the inflamed class and non-inflamed class. The inflamed class includes three distinct subclasses: the immune active, immune exhausted, and immune-like subclass. The non-inflamed class is composed of the immune intermediate and immune excluded subclasses. HCC, hepatocellular carcinoma; PD-L1, programmed death-ligand 1; PD-1, programmed cell death protein 1; TIL, tumor-infiltrating lymphocyte; TLS, tertiary lymphoid structure; TCR, T-cell receptor; CXCL, C-X-C motif chemokine ligand; CCL5, C-C motif chemokine ligand 5; TGF-β, transforming growth factor-β; PTK2, protein tyrosine kinase 2; IFN, interferon-related class; Pol7, class defined by polysomy of chromosome 7; amp., amplification; mut., mutation; ↑, increase; ↓, decrease.