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. 2023 Sep 7;15(18):4467. doi: 10.3390/cancers15184467

Figure 4.

Figure 4

MHC-I and PD-L1 are altered by methionine restriction in a model cell line. MR increased H2Kb gene expression in vitro in the cell line MC38 (A). The cell surface expression of MHC-I, however, decreased with MR (B). The gene expression for Cd274 also increased with MR (C), with a parallel increase in surface protein abundance (D). t-test with mean and SEM. Inhibiting JAK (interferon signaling) with 4 µM ruxolitinib led to a blunting of the effect of MR on Cd274 gene expression (E). Two-way ANOVA with mean and SEM.