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Dietary methionine restriction synergizes with ICIs in males. After subjecting the mice to a combination treatment consisting of anti-CTLA-4 and anti-PD-1 with MRD, females showed no benefit from MRD (A). In males, there was a 5× reduction in tumor volume with ICIs and MRD compared with ICIs alone (B) and (C). There was no significant change in body weight measured after 10 days of MRD (C).
