Table 2.
Mean absolute change % (95% CI) from baseline to 6 weeks for cognitive performance and PFC O2Hb.
| CR10 | CR20 | PLA | Interaction p-Value | |
|---|---|---|---|---|
| Cognitive test 1 | 3.6 (−3.4, 10.6) | 19 (−0.19, 38.2) | 18.7 (3.9, 33.5) | 0.17 |
| PFC O2Hb | −164.6 (−303.5, −25.7) | −100.3 (−217.1, 16.4) | 71.7 (−154.5, 297.8) | 0.07 |
| Cognitive test 2 | 11.7 (−4.6, 27.9) | 8.8 (−7.6, 25.3) | 10 (−0.5, 20.5) | 0.95 |
| PFC O2Hb | −15 (−157.1, 127.2) | −25.9 (−92.8, 40.9) | 81.6 (−162.1, 325.3) | 0.50 |
| Cognitive test 3 | 8.2 (−4.2, 20.7) | 11.5 (3.8, 19.2) | 4.9 (−4.8, 14.7) | 0.59 |
| PFC O2Hb | 7.5 (−98, 113) | −41.1 (−84, 1.9) | −13.8 (−175.3, 147.8) | 0.76 |
Abbreviations: CR10 = 10 g of creatine per day group; CR20 = 20 g of creatine per day group; O2Hb = oxygenated hemoglobin; PFC = prefrontal cortex; PLA = placebo group. Values are means (95% CI).