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. Author manuscript; available in PMC: 2024 Aug 3.
Published in final edited form as: Structure. 2023 Jun 20;31(8):987–1004.e8. doi: 10.1016/j.str.2023.05.017

Figure 6. Conformational dynamics of GRP94 Client-Binding Site.

Figure 6.

The client binding site is depicted as red (Protomer A) or blue (protomer B) ribbons, whereas the rest of the protein is depicted as transparent cartoons.

(a) 2GlycATP system.

(b) Same as A, for the N62Q mutant in complex with ATP.

(c) Same as A, for the N217A mutant in complex with ATP.

(d) Same as A, for the completely unglycosylated NoGlyc state in complex with ATP.