TABLE 3.
Adjusted a mortality hazard ratios (aHRs) for alcohol use category, stratified by calendar year period and HCV status (negative, positive, cured/cleared), splitting follow‐up time by HCV status.
| Alcohol use (grams per day) | HCV negative | HCV positive | Cured/cleared | |||
|---|---|---|---|---|---|---|
| Mortality rate per 1000 person‐years (95% CI) | aHR (95% CI) | Mortality rate per 1000 person‐years (95% CI) | aHR (95% CI) | Mortality rate per 1000 person‐years (95% CI) | aHR (95% CI) | |
| Follow‐up between 2001 and 2017 (N = 58,769) (interaction p‐value <0.001) | ||||||
| 0.0 g | 6.0 (5.7–6.3) | 1.18 (1.08–1.29) | 21.5 (19.5–23.7) | 1.00 (0.86–1.17) | 11.0 (8.4–14.4) | 1.13 (0.74–1.72) |
| 0.1–20.0 g | 5.5 (5.1–5.8) | 1 | 21.4 (19.0–24.0) | 1 | 8.7 (6.2–12.1) | 1 |
| >20.0 g | 10.4 (9.4–11.6) | 1.84 (1.62–2.09) | 28.6 (24.2–33.7) | 1.64 (1.33–2.02) | 15.2 (9.0–25.7) | 1.87 (1.00–3.48) |
| Follow‐up between 2001 and 2013 (N = 28,148) (interaction p‐value <0.001) | ||||||
| 0.0 g | 4.9 (4.5–5.3) | 1.21 (1.06–1.38) | 19.2 (17.0–21.8) | 0.97 (0.79–1.18) | 7.3 (3.9–13.5) | 0.58 (0.25–1.37) |
| 0.1–20.0 g | 4.4 (4.0–4.9) | 1 | 19.4 (16.7–22.5) | 1 | 9.9 (5.5–18.0) | 1 |
| >20.0 g | 9.3 (8.0–10.8) | 1.99 (1.64–2.40) | 26.3 (21.2–32.6) | 1.70 (1.29–2.23) | 3.9 (0.6–27.8) | 0.37 (0.05–2.87) |
| Follow‐up between 2014 and 2017 (N = 12,595) (interaction p‐value <0.001) | ||||||
| 0.0 g | 7.2 (6.7–7.7) | 1.17 (1.04–1.32) | 26.1 (22.4–30.3) | 1.04 (0.82–1.32) | 12.5 (9.3–16.8) | 1.35 (0.82–2.22) |
| 0.1–20.0 g | 6.6 (6.1–7.2) | 1 | 25.0 (20.9–29.9) | 1 | 8.2 (5.5–12.3) | 1 |
| >20.0 g | 11.6 (10.1–13.4) | 1.72 (1.45–2.04) | 32.7 (25.5–42.4) | 1.47 (1.07–2.03) | 19.6 (11.4–33.7) | 2.45 (1.24–4.82) |
Abbreviation: HCV, hepatitis C virus.
a
The covariates included were HIV acquisition group, female, prior AIDS status, age, CD4 count cells/μL and log HIV‐1 RNA copies/mL.