TABLE 4.
Causes of death stratified by baseline alcohol use category and HCV RNA status.
| Cause of death | All | HCV negative (N = 2723) | HCV positive (N = 876) | ||||
|---|---|---|---|---|---|---|---|
| (N = 3599) MR: 7.5 [7.2–7.7] | 0 g alcohol (N = 1356) MR: 6.1 [5.7–6.4] | 0.1–20.0 g alcohol (N = 1003) MR: 5.5 [5.2–5.8] | >20.0 g alcohol (N = 364) MR: 10.5 [9.5–11.6] | 0 g alcohol (N = 433) MR: 20.4 [18.6–22.4] | 0.1–20.0 g alcohol (N = 299) MR: 21.1 [18.8–23.6]) | >20.0 g alcohol (N = 144) MR: 28.0 [23.7–32.9] | |
| Liver | 242 (6.7%) | 34 (2.5%) | 23 (2.3%) | 27 (7.4%) | 76 (17.6%) | 58 (19.4%) | 24 (16.7%) |
| Unspecified viral hepatitis | 10 (0.3%) | 0 (0%) | 0 (0%) | 0 (0%) | 5 (1.2%) | 2 (0.7%) | 3 (2.1%) |
| HCV | 131 (3.6%) | 3 (0.2%) | 2 (0.2%) | 3 (0.8%) | 59 (13.6%) | 47 (15.7%) | 17 (11.8%) |
| HBV | 2 (0.1%) | 1 (0.1%) | 1 (0.1%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| Liver failure | 68 (1.9%) | 23 (1.7%) | 15 (1.5%) | 23 (6.3%) | 3 (0.7%) | 3 (1%) | 1 (0.7%) |
| Liver cancer | 31 (0.9%) | 7 (0.5%) | 5 (0.5%) | 1 (0.3%) | 9 (2.1%) | 6 (2%) | 3 (2.1%) |
| Substance use | 97 (2.7%) | 20 (1.5%) | 26 (2.6%) | 15 (4.1%) | 14 (3.2%) | 13 (4.3%) | 9 (6.3%) |
| Chronic alcohol use | 19 (0.5%) | 2 (0.1%) | 6 (0.6%) | 7 (1.9%) | 1 (0.2%) | 1 (0.3%) | 2 (1.4%) |
| Other/unspecified | 78 (2.2%) | 18 (1.3%) | 20 (2%) | 8 (2.2%) | 13 (3%) | 12 (4%) | 7 (4.9%) |
| AIDS | 815 (22.6%) | 344 (25.4%) | 234 (23.3%) | 66 (18.1%) | 86 (19.9%) | 58 (19.4%) | 27 (18.8%) |
| CNS‐related | 49 (1.4%) | 28 (2.1%) | 9 (0.9%) | 3 (0.8%) | 3 (0.7%) | 2 (0.7%) | 4 (2.8%) |
| Heart/vascular | 200 (5.6%) | 80 (5.9%) | 64 (6.4%) | 15 (4.1%) | 26 (6%) | 12 (4%) | 3 (2.1%) |
| Cardiovascular | 204 (5.7%) | 94 (6.9%) | 67 (6.7%) | 16 (4.4%) | 15 (3.5%) | 8 (2.7%) | 4 (2.8%) |
| Non‐AIDS infection | 235 (6.5%) | 98 (7.2%) | 57 (5.7%) | 20 (5.5%) | 26 (6%) | 23 (7.7%) | 11 (7.6%) |
| Non‐AIDS, non‐hepatitis, non‐liver malignancy | 668 (18.6%) | 277 (20.4%) | 214 (21.3%) | 74 (20.3%) | 47 (10.9%) | 36 (12%) | 20 (13.9%) |
| Respiratory | 121 (3.4%) | 49 (3.6%) | 34 (3.4%) | 12 (3.3%) | 16 (3.7%) | 10 (3.3%) | 0 (0%) |
| Unnatural | 178 (4.9%) | 55 (4.1%) | 60 (6%) | 29 (8%) | 14 (3.2%) | 18 (6%) | 2 (1.4%) |
| Other | 222 (6.2%) | 83 (6.1%) | 51 (5.1%) | 23 (6.3%) | 31 (7.2%) | 16 (5.4%) | 18 (12.5%) |
| Unknown | 568 (15.8%) | 194 (14.3%) | 164 (16.4%) | 64 (17.6%) | 79 (18.2%) | 45 (15.1%) | 22 (15.3%) |
Abbreviations: CNS, central nervous system; HBV, hepatitis B virus; HCV, hepatitis C virus; MR, mortality rate per 1000 person‐years.