Skip to main content
. Author manuscript; available in PMC: 2024 Oct 1.
Published in final edited form as: Curr Opin Chem Biol. 2023 Jul 1;76:102358. doi: 10.1016/j.cbpa.2023.102358

Figure 2.

Figure 2

Possible mechanisms of protein persulfidation and depersulfidation. (a) Transpersulfidation with the low molecular weight thiol hydropersulfide. A competing reaction, attack on the inner sulfur of the persulfide resulting in formation of the mixed disulfide and HS–, is not shown for clarity. Oxidation of cysteine to sulfenic acid by an oxidant, denoted [O], with subsequent attack by HS–. (c) Transpersulfidation by a persulfidated protein donor, for example, 3-MST. Trx, thioredoxin; TR, thioredoxin reductase. Similar chemistry can be performed by GR/Grx1 [24].