Figure 5.

Functions of SAHA in models of neurodevelopmental and psychiatric diseases: (A). Correction of autism-associated alterations, including repetitive behavior and social interaction deficits in fragile X syndrome (FXS) Fmr1 KO mice [51]. (B). Rescue of transcriptional defects affecting neuronal genes involved in ID (e.g., KDM5C, FMR1), ASD (e.g., GTF2I), and MDD (e.g., BDNF, GDNF) [14,32,51,52]; (C). Seizure frequency reduction in zebrafish and mouse Kcna1 null-mutants [53]. ID = intellectual disability; ASD = autism spectrum disorder; MDD = major depressive disorder; MO = morpholine; i.g.m = injection by a glass microelectrode in the tectum opticum; i.p. = intraperitoneal injection.