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. 2023 Sep 19;15(18):4635. doi: 10.3390/cancers15184635

Figure 1.

Figure 1

Transcriptomic pro-inflammatory signature is a prognostic marker for OsA’s metastatic spreading. (A) Characteristics of OsA cohorts; (B) MCPs score according to patients 5-years metastatic status. A higher score of genes linked to cytotoxic T-cells, monocyte lineage and NK cells was found in the 5-years metastatic-free group; (C) Expression of proinflammatory cytokines according to 5-years metastatic status. The expression of IL1β, IL6 and IFNγ was higher in the 5-years metastasis-free group; (D) Expression of antigen presentation related genes and TLR genes according to 5 years metastatic status. Higher score of activation of antigen presenting pathway, TLR pathway were found in the 5-year metastasis-free group; (E) Prognostic value of TLR4 expression for OsA’s metastatic spreading. A higher expression of TLR4 was associated with a significantly better metastasis free survival (p = 0.0035). * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001.