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. Author manuscript; available in PMC: 2024 Sep 8.
Published in final edited form as: Med. 2023 Jul 8;4(9):612–634.e4. doi: 10.1016/j.medj.2023.06.003

Figure 4. Unique spatial transcription markers in placentae depending on SARS-CoV-2 detection levels.

Figure 4.

(A) Differential expression between spatial transcriptomes in each analysis cohort relative to the negative controls identified 54 significantly differentially expressed transcripts (q<0.05, Log2(fold-change)>2) unique or shared between analysis cohorts. (B) The 37 transcripts unique to highly positive SARS-CoV-2 placentae were subject to EnrichR pathway analysis with the Reactome 2022 database, revealing the top 90th-quartile of significant (q<0.05) pathways. (C-D) Violin plots with the expression levels of KISS1 and TIMP1, which were markers for placentae where SARS-CoV-2 was not detected or highly positive, respectively. (E-F) Spatial gene expression of KISS1 and TIMP1 representative of each analysis cohort.