Figure 8. A proposed model on the role of CoRL in kidney repair and regeneration following the neonatal pUUO and release of obstruction:

CoRL increases significantly in the mesangial, epithelial, and SMCs of the kidneys persistently obstructed for 3W. The increase in the renin-producing cells and lineage cells during continued obstruction is a counter-productive regenerative response resulting in a failed repair. However, the sustained increase in the vasculature-specific renin lineage cells seen after the release of obstruction could promote kidney regeneration. Besides, ablation and depletion of renin-lineage cells impair these reparative responses, thus the ability of the kidney to recover and regenerate after removing the obstruction.