Table 3.
Numbers of RES with low stringencies for threshold values. The percentage of the RES in ADAR1KO in comparison to WT indicates the reduction in the number (#) of RES upon genetically ablating ADAR1, as expected. N/A represents not applicable.
| Sample Condition | Aligner | Tool | # RES | % (ADAR1KO/WT) |
|---|---|---|---|---|
| WT | BWA | RED-ML | 3949 | |
| ADAR1KO | BWA | RED-ML | 962 | 24 |
| WT | HISAT2 | RED-ML | 1976 | |
| ADAR1KO | HISAT2 | RED-ML | 206 | 10 |
| WT | STAR | RED-ML | 4262 | |
| ADAR1KO | STAR | RED-ML | 396 | 9 |
| WT | BWA | REDItools2 | 42,891 | |
| ADAR1KO | BWA | REDItools2 | 33,648 | 78 |
| WT | HISAT2 | REDItools2 | 15,083 | |
| ADAR1KO | HISAT2 | REDItools2 | 8234 | 55 |
| WT | STAR | REDItools2 | 21,734 | |
| ADAR1KO | STAR | REDItools2 | 11,651 | 54 |
| WT | BWA | SPRINT | 1358 | |
| ADAR1KO | BWA | SPRINT | 50 | 4 |
| WT | HISAT2 | SPRINT | 415 | |
| ADAR1KO | HISAT2 | SPRINT | 3 | 1 |
| WT | STAR | SPRINT | N/A | |
| ADAR1KO | STAR | SPRINT | N/A | N/A |
| WT | BWA | JACUSA2 | 20,048 | |
| ADAR1KO | BWA | JACUSA2 | 14,941 | 75 |
| WT | HISAT2 | JACUSA2 | 9642 | |
| ADAR1KO | HISAT2 | JACUSA2 | 6342 | 66 |
| WT | STAR | JACUSA2 | 14,681 | |
| ADAR1KO | STAR | JACUSA2 | 10,029 | 68 |