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. Author manuscript; available in PMC: 2024 Oct 1.
Published in final edited form as: Neurogastroenterol Motil. 2023 Jun 25;35(10):e14629. doi: 10.1111/nmo.14629

Figure 7. Modifications of Trp through the diet do not induce prokinetic effects on gut motility.

Figure 7.

To assess whether dietary-based alterations in Trp availability induce changes in colonic 5-HT signaling and intestinal motility, mice were fed for 10 days with either chow with no Trp (Trp -) or chow with twice as much Trp (Trp2x). (A) Mice that were fed the Trp2x diet (n=9) displayed significantly elevated levels of colonic Trp compared to mice that were fed the Trp - diet (n=9), and significantly elevated 5-HT compared to mice on the Trp - and control diets (n=8). (B) There was no significant change in whole gut transit or colonic motility following 10 days on a Trp– diet (n=10). (C) Mice exhibited slower whole gut transit time after 10 days on the Trp2x diet (n=10). There was no significantly change in colonic motility. Data are shown as mean ± SEM (A), one-way ANOVA with Tukey’s post-hoc multiple comparisons test, or as individual animals (B,C), paired Student’s t-test. * p < 0.05, ** p < 0.01, *** p < 0.001.