Table 2.
Hemostatic biomarkers and Thrombin generation according to VTE and death.
| Reference Value | VTE Free (n = 506) |
VTE (n = 62) |
p-Value | Survivors (n = 401) |
Non-Survivors (n = 167) |
p-Value | |
|---|---|---|---|---|---|---|---|
| F1 + 2, pmol/L | 215 (126–478) | 255 (128–826) | 338 (135–1122) | 0.001 | 283 (144–824) | 293 (141–1033) | 0.151 |
| D-dimer, ng/mL | 110 (40–280) | 1330 (170–5620) | 2030 (160–8340) | 0.002 | 620 (150–4800) | 1230 (270–7600) | <0.001 |
| Fibrinogen, mg/dL | 150–400 | 475 (248–922) | 444 (201–800) | 0.231 | 475 (245–908) | 524 (240–1061) | <0.001 |
| FVIII, % | 104 (73–145) | 155 (75–295) | 190 (92–362) | 0.007 | 150 (71–250) | 186 (101–280) | <0.001 |
| Free PS, % | 90 (70–120) | 86 (59–116) | 87 (58–116) | 0.645 | 86 (59–116) | 89 (59–110) | 0.316 |
| PC, % | 98 (72–125) | 120 (82–182) | 132 (78–204) | 0.025 | 120 (82–202) | 124 (82–188) | 0.951 |
| TG lag time, min | 3.1 (2.2–4.5) | 3.3 (2.2–5.4) | 3.1 (2.0–4.6) | 0.023 | 3.2 (2.1–4.8) | 3.3 (2.3–5.0) | 0.042 |
| TG ETP, nM*min | 1702 (962–2601) | 1847 (1228–2730) | 1836 (1124–2993) | 0.736 | 1853 (1279–2874) | 1837 (1164–3033) | 0.630 |
| TG ttP, min | 6.7 (4.7–8.8) | 5.7 (4.1–8.6) | 5.1 (3.7–7.4) | 0.001 | 5.5 (4.0–8.2) | 5.4 (4.1–8.1) | 0.647 |
| TG peak, nM | 237 (128–404) | 390 (210–598) | 432 (278–592) | 0.002 | 400 (206–591) | 424 (244–642) | 0.025 |
Data are presented as median and 5th and 95th percentiles. The p-value is the statistical significance of the Mann-Whitney U test to compare values between VTE patients versus VTE-free and non-survivor versus survivor patients. VTE: venous thromboembolism; F1 + 2: prothrombin fragment 1 + 2; FVIII: factor VIII; free PS: free protein S; PC: protein C; TG: thrombin generation; ETP: endogenous thrombin potential; ttP: time to peak.