Table 1.

Oncological outcomes of Radical Nephroureterectomy: literature overview.

Study Name	Year	Type of Study	N of Cases	Topic	Main Results
Inamoto [34]	2018	Retrospective two-arm comparative study	163	Variant Histology p-CIS vs. c-CIS	10 yrs CSS: p-CIS 111.8 months c-CIS 85.9 months
Upfill-Brown [35]	2019	Retrospective two-arm comparative study (NCDB Database)	16,783	Nephroureterectomy vs. Endoscopic Management	ET worse OS vs. RNU (HR 1.43; p = 0.006)
Nazzani [36]	2020	Retrospective two-arm comparative study (SEER Database)	4266	RNU + BCE vs. RNU	5 yrs CSM: BCE 19.7% vs. No BCE 23.5% (p = 0.005) ± BCE (HR 1.14; p = 0.1)
Peyronnet [22]	2019	Meta-analysis	7554	Laparoscopic vs. Open RNU	CSS, RFS, MFS: p = 0.2, p = 0.86, and p = 0.12 pT3/HG Open vs. Lap (p < 0.05)
Veccia [37]	2020	Meta-analysis	87,291	Robotic vs. Lap vs. Open RNU	RANU vs. Lap vs. Open RFS: 0.99; CSS: 0.83
Mori [38]	2020	Meta-analysis	12,865	Variant Histology	CSS: HR 2.00 OS: HR 1.76 RFS: HR 1.64
Kawada [39]	2023	Meta-analysis	N/A	Nephroureterectomy vs. Endoscopic Management	OS: HR 1.27 CSS: HR 1.37