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Mode of action of PROTACs (Made using Biorender (licensed)). 1. PROTAC recruits the E3 ligase complex to the POI by binding both the POI and E3 ligase. 2. The E3 ligase complex induces ubiquitination of the POI. 3. The POI gets polyubiquitinated and subsequently degraded via the 26S proteasome. The PROTAC gets recycled, and the process is repeated.
