Table 1.

Demographic, clinical, cognitive, and biomarkers among male and female PSEN1 mutation carriers and non-carriers

	Non-carriers			Cognitively Unimpaired Carriers			Cognitively Impaired Carriers
	Mean±SD		p a	Mean±SD		p b	Mean±SD		p c
	Males n = 101	Females n = 155		Male n = 118	Female n = 141		Male n = 48	Female n = 58
Age, years	33.42±10.29	35.08±9.53	.186	31.98±9.14	31.70±9.26	.813	49.04±4.63	48.85±4.59	.827
Education, years	8.13±4.72	8.46±4.32	.566	7.90±4.43	8.77±4.24	.109	4.85±3.78	5.36±3.66	.485
Body Mass Index, kg/m2	22.74±2.89	23.88±3.76	.059	22.40±3.17	23.15±3.40	.142	22.51±2.79	23.47±2.57	.172
MMSE score	28.78±1.70	28.83±1.97	.846	28.80±1.55	28.67±1.87	.548	19.50±7.02	16.85±7.16	.083
API Cognitive Composite Score	82.59±11.23	81.65±10.08	.501	79.51±12.81	79.05±12.26	.768	36.75±14.74	34.63±14.28	.495
CERAD Word List Delayed Recall	6.30±1.88	6.40±2.00	.708	5.59±2.11	5.98±2.04	.136	0.76±1.37	0.88±1.45	.697
Plasma P-tau217, pg/ml	1.92±1.46	1.85±1.45	.696	4.69±3.95	4.42±5.78	.662	16.14±6.81	17.42±7.20	.352
Plasma NfL, pg/ml	7.33±3.98	6.57±2.91	.082	9.74±6.34	7.97±4.45	.009	24.92±12.11	33.32±24.12	.023

Note. Abbreviations: MMSE, Mini-Mental Status Exam; CERAD, Consortium to Establish a Registry for AD; API, Alzheimer Prevention Initiative.

^ap-value as defined by an independent two sample t-test for male vs female non-carriers.

^bp-value as defined by an independent two sample t-test for male vs female cognitively unimpaired mutation carriers.

^cp-value as defined by an independent two sample t-test for male vs female symptomatic mutation carriers.