Table 2.
Regression estimates of the effect of sex on the relationship between plasma biomarkers and cognition among PSEN1 mutation carriers with and without age as a covariate.
| Model 1 | Model 2 (Adjusting for Age) | ||||
|---|---|---|---|---|---|
| Outcome Variable | Predictors | Standardized β | p-value | Standardized β | p-value |
| API Cognitive Composite Score | Sex | −2.09 | .037 | −1.524 | .129 |
| Plasma P-tau217 | −7.683 | <.001 | −4.357 | <.001 | |
| Sex*P-tau217 | 2.73 | .007 | 1.537 | .125 | |
| Age | . | . | −12.142 | <.001 | |
| CERAD Word List Delayed Recall | Sex | −.285 | .775 | .396 | .692 |
| Plasma P-tau217 | −6.909 | <.001 | −3.910 | <.001 | |
| Sex*P-tau217 | 2.093 | .037 | 1.039 | .299 | |
| Age | . | . | −9.923 | <.001 | |
| API Cognitive Composite Score | Sex | −1.492 | .137 | −1.030 | .304 |
| Plasma NfL | −6.846 | <.001 | −3.610 | <.001 | |
| Sex*NfL | .943 | .347 | .611 | .541 | |
| Age | . | . | −8.065 | <.001 | |
| CERAD Word List Delayed Recall | Sex | −.805 | .421 | −.404 | .686 |
| Plasma NfL | −6.075 | <.001 | −3.214 | .001 | |
| Sex*NfL | .858 | .391 | .624 | .533 | |
| Age | . | . | −6.957 | <.001 | |
Note. Abbreviations: PSEN1 status, PSEN1 Carriers/Non-carriers; P-tau217, Plasma P-tau217 pg/ml; NfL, Plasma NfL pg/ml; API, Alzheimer Prevention Initiative; CERAD, Consortium to Establish a Registry for AD. Bold text represents p-value <.05.