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. 2023 Sep 6;13(9):1355. doi: 10.3390/biom13091355

Figure 3.

Figure 3

Effects of loperamide on QT interval, QRS duration, and iCEB (QT/QRS ratio) in the isolated rabbit ventricular wedge. There were no significant effects on QT interval up to 1 µM and iCEB up to 0.3 µM. Significant shortening in QT interval at 3 µM, Panel (A), and iCEB, Panel (C), at 1 and 3 µM and increases in QRS duration, Panel (B), starting at 0.3 µM. Panel (D) shows an example of ventricular couplets in a preparation exposed to loperamide at 3 µM). Panel (E) shows a non-TdP-like ventricular tachycardia (VT) in another preparation exposed to loperamide at 10 µM (24,800× FTPC). * p < 0.05 vs. solvent control.