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. 2023 Sep 6;13(9):1355. doi: 10.3390/biom13091355

Figure 4.

Figure 4

Effects of loperamide on QTcB interval (A), JT (B), QRS duration (C), PQ-interval (D), and iCEB (QT/QRS ratio) (E) in the anesthetized guinea pigs. (F,G): ECG recordings in the anesthetized guinea pig; Loperamide up to 0.63 mg/kg i.v. (G) had no significant effects on ECG parameters. Starting at 1.25 mg/kg i.v., (H) loperamide significantly changed ECG parameters: at 2.5 mg/kg i.v., loperamide caused AV-block type II (I) and AV-block type III at 5 mg/kg i.v. (J). * p < 0.05 vs. solvent control.