Table 2.

Risk of Stroke by TBI Status.

	Veterans Without TBI	Veterans With TBI
Any Stroke
No. Events/No. PYs	10,297/1,811,490	18,435/1,787,238
Unadjusted Incidence Rate per 1,000 PYs (95% CI)	5.7 (5.4-6.0)	10.3 (10.0-10.7)
Adjusted* Cox proportional hazards model, HR (95% CI)	1 (Reference)	1.80 (1.76-1.85)
Adjusted* Fine-Gray proportional hazards model, HR (95% CI)	1 (Reference)	1.69 (1.64-1.73)**†
Ischemic Stroke
No. Events/No. PYs	9,924/1,812,455	16,645/1,795,283
Unadjusted Incidence Rate per 1,000 PYs (95% CI)	5.5 (5.2-5.7)	9.3 (8.9-9.6)
Adjusted* Cox proportional hazards model, HR (95% CI)	1 (Reference)	1.68 (1.63-1.72)
Adjusted* Fine-Gray proportional hazards model, HR (95% CI)	1 (Reference)	1.56 (1.52-1.61)**†
Hemorrhagic Stroke
No. Events/No. PYs	660/1,848,365	2,603/1,851,144
Unadjusted Incidence Rate per 1,000 PYs (95% CI)	0.4 (0.3-0.4)	1.4 (1.3-1.5)
Adjusted* Cox proportional hazards model, HR (95% CI)	1 (Reference)	3.92 (3.59-4.29)
Adjusted* Fine-Gray proportional hazards model, HR (95% CI)	1 (Reference)	3.73 (3.40-4.08)**†

^*Model adjusted for demographics (age, sex, race/ethnicity, income, education, and current smoking), medical comorbidities (hypertension, hyperlipidemia, diabetes, coronary artery disease, and atrial fibrillation) and psychiatric comorbidities (post-traumatic stress disorder and depression).

^**P-interaction by age <0.001

^†P-Interaction by race/ethnicity <0.001