HF	Heart failure
HFrEF	Heart Failure with reduced ejection fraction
SR	Sarcoplasmic reticulum
ER	Endoplasmic reticulum
ATP	Adenosine triphosphate
Ca2+	Calcium
ROS	Reactive oxygen species
RyR2	Ryanodine receptor type 2
IP3Rs	1,4,5-trisphosphate receptors
EC	Excitation–contraction
ETC	Electron transport chain
NADH	Nicotinamide adenine dinucleotide
FADH2	Flavin adenine dinucleotide
ADP	Adenosine diphosphate
CK	Creatine kinase
CICR	Calcium-induced calcium release
SERCA2a	Sarco(endo)plasmic reticulum calcium-ATPase 2a
NCX	Sarcolemmal Na+/Ca2+ exchanger
TNF-⍺	Tumor necrosis factor
IL-17	Interleukin-17
IL-6	Interleukin-6
IL-1ß	Interleukin-1
TGF-ß	Transforming growth factor
NOX2	NADPH oxidase 2
O2·−	Superoxide radical
MCU	Mitochondrial Ca2+ uniporter
mNCLX	Mitochondrial Na+-Ca2+—Li+ exchanger
Letm1	Mitochondrial proton/calcium exchanger protein
TRPC3	Transient receptor potential canonical 3
MFN2	Mitofusin2
MFN1	Mitofusin1
Grp75	Chaperone glucose-regulated protein 75
VDAC	Voltage-dependent anion channel
mPTP	Mitochondrial permeability transition pore
MAM	Mitochondria-associated membrane
LBD	Ligand-binding domain (LBD)
PDZD8	PDZ-domain-containing 8
Rab7	Ras-related protein Rab-7a
FUNDC1	FUN14-domain-containing 1
PTPIP51	Protein tyrosine phosphatase-interacting protein 51
VAPB	Vesicle-associated membrane protein-associated protein B
·OH	Hydroxyl radical
H2O2	Hydrogen peroxide
SOD	Superoxide dismutase
Prx	Peroxiredoxin
Gpx	Glutathione peroxidase
Cryo-EM	Cryogenic-electron microscopy
NTD	N-terminal domain
CPVT	Catecholaminergic polymorphic ventricular tachycardia
SPRY1	SPIa kinase and ryanodine receptor
Bsol	Bridging solenoid
PKA	Protein kinase A
CamKII	Ca2+/calmodulin-dependent protein kinase II
cAMP	3′,5′-cyclic adenosine monophosphate
hiPS	Human-induced pluripotent stem