Figure 6.

Examples of interaction among noncoding RNAs to control the transcriptional state switch. In Fig. 2b, two interacting negative-feedback loops composed of transcriptional factors and miRNA form a genetic circuits for three cell states (epithelial, EMT, and mesenchymal), and SNAIL1 receives the input signal TGFβ. Alternatively, input signal, such as TGFβ and hypoxia, can control this circuit by inducing lncRNAs that suppress miR-200 family (Li et al., 2016; Liu et al., 2018; Raveh et al., 2015; Yuan et al., 2014) or miR-34 by sponging them. This adds another level of regulation of melanoma plasticity. Part of the figure is generated using birender.com (2022).