Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Sep 11;12(18):2253. doi: 10.3390/cells12182253

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Schematic representation of mentioned delivery strategies applied to oligonucleotides. (A): (A1) Receptor agonist conjugates as exemplified with the GLP1R peptide agonist-ASO conjugate, (A2) GalNAc conjugate as found in liver targeting therapeutics, and (A3) lipid conjugates exemplified with the 2′-O-hexadecyl modified siRNA; (B): (B1) antibody–oligonucleotide conjugate, and (B2) divalent siRNAs scaffold; (C): (C1) LNPs as for instance used in patirisan, (C2) dendrimer–oligonucleotide complexes like PANAM, (C3) exosome delivery, (C4) DNA-nanoconstruct like the tetrahedron DNA origami, functionalized with an ASO, and (C5) spherical nucleic acid, made with a gold nanoparticle and packed ASOs. Figure created with BioRender.com, FU25OEFFUQ.