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. 2023 Sep 11;12(18):2253. doi: 10.3390/cells12182253

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Oligonucleotides containing triazole linkages formed using SPAAC reaction. (A) mAb-siRNA conjugates containing DBCO as strained alkyne; (B) Ang II peptide-ASO conjugate containing BCN as strained alkyne.