Table 2.

Sex-by-lipid interaction and sex-specific associations of lipid variables with change in SPARE-BA index score

		Interaction (n=475)		Men (n=214)		Women (n=261)
Lipid class	Variables	β (95% CI)	p-value	β (95% CI)	P-value	β (95% CI)	P-value
Acylcarnitines	Beta-oxidation rate	0.181 (0.0002, 0.361)	0.0497	0.057 (0.091, 0.205)	0.450	−0.128 (0.239, 0.018)	0.023
	Long-chain	0.040 (−0.141, 0.222)	0.663	0.024 (0.127, 0.175)	0.757	−0.020 (0.132, 0.092)	0.724
	Medium-chain	0.099	0.298	0.045	0.595	−0.059	0.263
		(−0.088, 0.287)		(0.122, 0.212)		(0.162, 0.044)
	Short-chain	0.196 (0.012, 0.379)	0.036	0.068 (0.088, 0.225)	0.392	−0.128 (0.234, 0.022)	0.018
Ceramides	Very Long-chain	0.041 (−0.143, 0.225)	0.662	0.112 (0.034, 0.259)	0.132	0.067 (0.054, 0.188)	0.275
	Long-chain	0.196 (0.010, 0.381)	0.039	0.207 (0.061, 0.352)	0.006	0.002 (0.120, 0.124)	0.971
Glycosylceramides	Very Long-chain	0.044 (−0.139, 0.228)	0.634	0.044 (0.101, 0.190)	0.551	0.019 (0.101, 0.140)	0.753
	Long-chain	0.083 (−0.102, 0.269)	0.379	0.053 (0.088, 0.193)	0.458	−0.010 (0.137, 0.117)	0.877
Glycerolipids & Cholesteryl Esters	Very Long-chain	0.108 (−0.079, 0.294)	0.257	0.009 (0.137, 0.156)	0.901	−0.085 (0.206, 0.037)	0.172
	Long-chain	0.113 (−0.074, 0.300)	0.237	0.112 (0.042, 0.265)	0.153	−0.004 (0.124, 0.116)	0.946
Sphingomyelins	Very Long-chain	−0.046 (−0.238, 0.146)	0.637	−0.039 (0.188, 0.110)	0.611	−0.002 (0.127, 0.123)	0.971
	Long-chain	0.053 (−0.059, 0.353)	0.607	0.030 (0.128, 0.189)	0.707	−0.024 (0.154, 0.106)	0.716
Triglycerides	Very Long-chain	0.190 (0.011, 0.369)	0.037	0.149 (0.011, 0.286)	0.035	−0.061 (0.181, 0.060)	0.324
	Long-chain	0.157 (−0.022, 0.337)	0.085	0.153 (0.015, 0.291)	0.030	−0.028	0.650

Note: Bold number indicates significant associations at two-tailed p<0.05. All models were adjusted for baseline age, race, education, and baseline SPARE-BA score. The reported beta is equivalent to Cohen’s d effect size (per standard deviation change in the independent variable).The interaction effects did not survive FDR-adjusted p<0.05.