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. Author manuscript; available in PMC: 2024 Aug 1.
Published in final edited form as: Brain Behav Immun. 2023 Jun 12;112:220–234. doi: 10.1016/j.bbi.2023.06.011

Fig. 1.

Fig. 1.

Role of Pi16 deletion in inflammatory pain. (A, D) Inflammatory pain was induced by intraplantar CFA injection. Mechanical allodynia was assessed at baseline and over time using von Frey filaments in female (A) and male (D) mice. Mixed-effects analysis, Šidák’s multiple comparisons test: WT CFA vs Pi16−/− CFA: *P<0.05, **P<0.01, ***P<0.005, ****P<0.0001, WT PBS vs WT CFA: #P<0.05, ###P<0.01, ####P<0.0001. (B, E) Thermal sensitivity was assessed at baseline and over time in female (B) and male (E) mice using Hargreaves’ test. Mixed-effects analysis, Šidák’s multiple comparisons test: *P<0.05, **P<0.01, ***P<0.005, ****P<0.0001. (C, F) Hind paw thickness at baseline and over time following intraplantar CFA injection in female (C) and male (F) mice was measured using a Digimatic micrometer. Two-way ANOVA, Šidák’s multiple comparisons test.