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. Author manuscript; available in PMC: 2024 Aug 1.
Published in final edited form as: Brain Behav Immun. 2023 Jun 12;112:220–234. doi: 10.1016/j.bbi.2023.06.011

Fig. 2.

Fig. 2.

Hindpaw von Frey following CFA in systemic inducible Pi16−/− (A-B) and fibroblast-specific inducible Pi16−/− (C-D). Cre-positive (Cre+) or wild-type littermate controls (WT) were treated with vehicle (VEH) or tamoxifen (TAM) between baseline measurements 1 and 2 (days −7 and −1 relative to intraplantar CFA). (A, B) Systemic inducible deletion of PI16 protects females from acute and prolonged CFA-induced hypersensitivity, whereas males only show attenuation of pain up to 11–15 days post-CFA. (C, D) Inducible deletion of PI16 from Col1a2 fibroblasts protects female (C) and male (D) mice from prolonged CFA-induced mechanical hypersensitivity. Merged results from (C) and (D) are depicted in panel (E). Two-way repeated-measures ANOVA, Šidák’s multiple comparisons tests: Cre+ + TAM vs WT + TAM: *P<0.05, **P<0.01, ***P<0.005, ****P<0.0001. Cre+ + TAM vs Cre+ + VEH: #P<0.05, ##P<0.01, ####P<0.0001.