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. Author manuscript; available in PMC: 2024 Aug 1.
Published in final edited form as: Brain Behav Immun. 2023 Jun 12;112:220–234. doi: 10.1016/j.bbi.2023.06.011

Fig. 9.

Fig. 9.

The effect of PI16 on inflammatory pain is mediated by extracellular PI16. anti-PI16 antibody or IgG isotype control were intrathecally injected (i.t.) on days 1, 2 and 4 following intraplantar CFA in WT female mice (n=12). On days where i.t. injections occurred, von Frey thresholds were measured prior to injections. Mice that received i.t. anti-PI16 show statistically significant recovery from CFA-induced hypersensitivity 7–17 days post-CFA. Two-way repeated-measures ANOVA, Bonferroni analysis: ***P<0.005, ****P<0.0001.