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. Author manuscript; available in PMC: 2024 Sep 1.
Published in final edited form as: Semin Immunol. 2023 Jul 26;69:101815. doi: 10.1016/j.smim.2023.101815

Figure 2. Inflammasomes regulate physiologic processes.

Figure 2.

(A) Embryogenesis is regulated by NLRP2, NLRP5, and NLRP9, while spermatogenesis is regulated by NLRP14. Sensing of cytosolic nucleic acids may serve as a central regulator of both reproductive processes.

(B) Development generates cytosolic dsDNA which signals through AIM2 to control neuronal pruning. It is proposed that Pyrin senses changing Rho-GTPase activity to regulate unknown features of development.

(C) Multiple inflammasomes are proposed to regulate tumorigenesis through diverse pathways, some of which may be independent of inflammatory caspase activity.