Table 2.

Common mutations in different histologic subtypes of thymoma.

Molecular Alteration	Thymoma Histologic Subtypes
Loss of heterozygosity across chromosome 6 (FOXC1 6q25.2-p25.3)	Common in thymoma type A, type AB, type B2, and type B3
Missense mutations in in GTF2I p.L424H	Mainly in thymomas type A and type AB (38% of cases)
HRAS gene mutation	Restricted to type A and AB thymomas
NRAS and TP53 gene mutations	Common in type B2 and B3 thymomas and thymic carcinomas
GTF2I and BCOR mutations	Mutually exclusive in thymomas from individuals with Myasthenia Gravis