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. Author manuscript; available in PMC: 2024 Aug 9.
Published in final edited form as: Cell Host Microbe. 2023 Jul 28;31(8):1288–1300.e6. doi: 10.1016/j.chom.2023.07.002

Figure 2. Two human mAbs strongly bind to both RSV and hMPV F proteins and compete for binding.

Figure 2.

(A) ELISA binding of RSV-199, MEDI8897, MPE8, RSV-90 or rDENV-2D22 to hMPV prefusion F protein, RSV strain A2 pre-fusion F protein (SC-TM) or RSV strain A2 post-fusion F protein. Data are mean ± standard deviations (S.D.) of technical triplicates from a representative experiment repeated twice. (B) Competition-binding of monoclonal antibodies reactive with hMPV prefusion F protein. Values in squares are the percent binding of the monoclonal antibody in the presence of the competing monoclonal antibody relative to a mock-competition control. Black squares indicate full competition (<33% relative binding); grey squares indicate intermediate competition; white squares indicate no competition (>67% relative binding).