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. Author manuscript; available in PMC: 2024 Aug 1.
Published in final edited form as: Biochem Pharmacol. 2023 Jun 20;214:115665. doi: 10.1016/j.bcp.2023.115665

Figure 2. CB1R modulation of intracellular signaling pathways.

Figure 2.

Agonist-induced activation by CB1R causes inhibition of VGCCs and adenylyl cyclase and production of cAMP while stimulating GIRK potassium channels and MAPK signaling pathways such as extracellular-regulated kinase (ERK) 1/2, JNK, and p38. Activation of CB1R also increases PKC and PI3K signaling pathways. A major overall effect of CB1R activation is that it inhibits neuronal signaling by preventing neurotransmitter release (inhibition of VGCCs) and hyperpolarization of the membrane potential (activation of GIRKs).