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. Author manuscript; available in PMC: 2023 Sep 27.
Published in final edited form as: J Biomed Inform. 2023 Jun 1;143:104405. doi: 10.1016/j.jbi.2023.104405

Statement of significance

Problem or Issue What is Already Known What this Paper Adds
No knowledge-base focused on scientific knowledge goals from the literature exists to provide insights for contextualizing topics and experimental results in our collective scientific ignorance. Knowledge-bases exist to find information and contextualize experimental results in what is known. Known unknowns are important and studied under different focuses. One search engine exists to help scientists discover challenges and directions. This study aims to create an ignorance-base focused on knowledge goals to provide insights to researchers interested in exploring a topic or contextualizing experimental results in the known unknowns. We found emerging and currently studied avenues ripe for future work.