Table 1.

Reaction Conditions Optimization.

Entry	Ligand	Solvent	Time	Yield[a]	ee[b]
1	WangPhos	DCM	<15 min	90%	NA
2	(S)-L1	DCM	2 h	91%	−26%
3	(S)-L2	DCM	<15 min	95%	94%
4	(S)-L3	DCM	<15 min	86%	94%
5	(S)-L4	DCM	<15 min	90%	98%
6	(S)-L5	DCM	30 min	87%	−64%
7	(S)-L4	THF	24 h	14%	NA
8	(S)-L4	PhCF3	<15min	83%	97%
9	(S)-L4	toluene	30 min	95%	92%
10	(S)-L4	DCE	<15 min	89%	98%
11	(S)-L4[c]	DCM	<15 min	88%	98%
12	(S)-L4[d]	DCM	<15 min	89%	98%

^[a]Determined by ¹H NMR using diethyl phthalate as the internal standard.

^[b]Determined by chiral HPLC.

^[c]5 mol% AgNTf₂ was used instead of 10 mol% NaBARF.

^[d]5 mol% AgSbF₆ was used instead of 10 mol% NaBARF.