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Hypercapnic ventilatory response of adult rats (Crl:SD) after 7 days in 21% O2 (Control) or 12% O2 (CH). Ventilation (mean±SEM) was measured in 0% CO2 (21% O2, balance N2) and then in 7% CO2 (21% O2, balance N2). Sample sizes (n) were Control: 9 females, 7 males and CH: 6 females, 9 males. * P≤0.05 vs. Control across both inspired CO2 levels (i.e., main effect for treatment group).
