Table 2:

Spearman’s correlation values (r) and p-values measuring the association between MØ morphological parameters and diffusion MRI (dMRI) metrics for each region of interest (ROI), ranked by higher p-value; region of interest (ROI) abbreviations: corpus callosum (CC), fimbria (Fi), ventral (HV) hippocampus, subiculum (Sub), cingulate cortex (Ctx_Cg) and retrosplenial cortex (Ctx_Rsp). Mean diffusivity (MD), axial diffusivity (D_||), radial diffusivity (D_⊥), fractional anisotropy (FA), radial kurtosis (K_⊥), and kurtosis fractional anisotropy. NC: control mice; TG: 3xTg-AD mouse; ALL: both groups pulled together.

ROI	Group	MØ Metric	dMRI Metric	r	p-value
CC	ALL	Cells n	D⊥	0.590	0.008
Sub	ALL	Density	D∥	0.573	0.010
CC	ALL	Cells n	KFA	−0.549	0.015
Ctx Cg	ALL	Density	KFA	0.539	0.017
Fi	ALL	Span Ratio	FA	0.514	0.024
CC	ALL	Span Ratio	K⊥	0.513	0.025
Fi	ALL	Cells n	D∥	−0.469	0.043
CC	ALL	Cells n	FA	−0.496	0.031
Fi	ALL	Span Ratio	KFA	0.490	0.033
HV	ALL	Density	D∥	0.487	0.034
Ctx Rsp	ALL	Cells n	D∥	0.476	0.039
Sub	ALL	Density	MD	0.456	0.050