Figure 1: Metabolic and Neurodegenerative Disease Cellular Pathways.
A number of metabolic and neurodegenerative cellular pathways rely upon the mechanistic target of rapamycin (mTOR) and its associated pathways of mTOR Complex 1 (mTORC1), mTOR Complex 2 (mTORC2), AMP activated protein kinase (AMPK), and p70 ribosomal S6 kinase (p70S6K). Intimately linked to these pathways are trophic factors, such as erythropoietin (EPO), apoptosis, autophagy, and inflammation that can involve pyroptosis.