Figure 6.

PEP-1 reduces leukocyte infiltration in the colon LP of IL-KO mice. Mice were sacrificed to estimate the infiltration of immune cells in the sub-mucosal tissues through histological examination by H&E staining (A). Lamina propria was infiltrated by inflammatory cells (arrowhead) in IL-10KO mice treated with scrambled peptide, unlike the result observed in mice treated with PEP-1. Subsequently, leukocytes infiltrated in LP were isolated, and the cell count was carried out (B) in mice treated with scramble or PEP-1. The graph represents mean ± SEM. * p < 0.05. p-values were calculated using the unpaired Student’s t-test. Each dot represents an individual mouse. (n = 8/group).