Figure 9.

PEP-1 ameliorates clinical signs of colitis in DNBS-induced colitis mice. Before sacrifice, daily measurement of total disease score was conducted in SHAM and PEP-1 treated mice during DNBS-induced colitis (A). Following that, colon tissues from mice treated only with vehicle (SHAM), DNBS-induced colitis mice (DNBS), and DNBS-treated mice with PEP-1 injection (DNBS + PEP-1) were examined under a microscope (B), and the ratio weight/length of the colon was calculated (C); lymphocytes infiltrated in LP were isolated and counted from SHAM, DNBS-induced colitis mice, treated or not with PEP-1 (D). Graphs represent mean ± SEM. ** p < 0.005. p-values were calculated using the unpaired Student’s t-test. ns: non-significant. (n = 6/group).